IL-1B (PN0163) Nb-FC recombinant antibody
- 货号：YA0608
- 应用：ELISA
- 种属：Human
- 蛋白名称：
- Interleukin-1 beta (IL-1 beta) (Catabolin)
- 免疫原：
- Purified recombinant Human IL-1B
- 特异性：
- This recombinant monoclonal antibody can detects endogenous levels of IL-1B protein.
- 组成：
- Phosphate-buffered solution
- 来源：
- Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
- 纯化工艺：
- Recombinant Expression and Affinity purified
- 浓度：
- Please check the information on the tube
- 储存：
- -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
- 其他名称：
- IL-1;IL1F2;IL1beta;IL1-BETA;Catabolin antibody;H1 antibody;IFN beta inducing factor antibody;IL 1 antibody;IL 1 beta antibody;IL-1 beta antibody;IL1 antibody;IL1 BETA antibody;IL1B antibody;IL1B_HUMAN antibody;IL1F2 antibody;Interleukin 1 beta antibody;Interleukin 1 beta precursor antibody;interleukin 1;beta antibody;Interleukin-1 beta antibody;OAF antibody;Osteoclast activating factor antibody;OTTHUMP00000162031 antibody;Preinterleukin 1 beta antibody;Preinterleukin beta antibody;Pro interleukin 1 beta antibody;IL-1β;IL-1B nanobody;
- 背景：
- IL-1β in humans and mice does not encode a typical signal peptide and, as a result, newly synthesized pro-IL-1β accumulates within the cytoplasm of activated monocytes and macrophages . Conversion of the inactive pro-IL-1β to its mature form requires the proteolytic action of IL-1β-converting enzyme (ICE), also termed caspase-1 . Secretion of mature IL-1β from LPS-activated monocytes/macrophages is not a constitutive process. These cells must encounter a secondary stimulus that specifically activates the posttranslational processing events . Moreover, owing to its pro-inflammatory nature, IL-1β is regarded as a tumor-promoting cytokine. In fact, enhanced tumor metastasis and angiogenesis has been observed under the influence of IL-1β . IL-1β is able to facilitate tumor progression in murine models of lung cancer. In addition, upregulation of metastasis and tumor angiogenesis by IL-1β has been associated with increased activity of matrix metalloproteinases and expression of the pro-angiogenic molecule hepatocyte growth factor .
- 功能：
- Interleukin (IL)-1β is a cytokine with a key role in the pathophysiology of local and systemic inflammation. IL-1β induces cytokine, chemokine, proinflammatory molecule secretion, and adhesion molecule expression in diverse cells.
- 细胞定位：
- Cytoplasm, cytosol . Secreted . Lysosome . Secreted, extracellular exosome . The precursor is cytosolic (PubMed:15192144). In response to inflammasome-activating signals, such as ATP for NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome, cleaved and secreted (PubMed:24201029, PubMed:33377178, PubMed:33883744). Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744). In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation (PubMed:33883744). The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10 (PubMed:32272059). .
- 组织表达：
- Expressed in activated monocytes/macrophages (at protein level).
