• 靶点：
• FoxD3

• 基因名称：
• FOXD3

• 蛋白名称：
• Forkhead box protein D3

• Human Gene Id：
• 27022

• Human Swiss Prot No：
• Q9UJU5

• Mouse Gene Id：
• 15221

• Mouse Swiss Prot No：
• Q61060

• 免疫原：
• Purified recombinant fragment of human FoxD3 expressed in E. Coli.

• 特异性：
• FoxD3 Monoclonal Antibody detects endogenous levels of FoxD3 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Monoclonal, Mouse

• 稀释：
• WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200

• 纯化工艺：
• Affinity purification

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• FOXD3;HFH2;Forkhead box protein D3;HNF3/FH transcription factor genesis

• 分子量：
• 48kD

• 背景：
• This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. Mutations in this gene cause autoimmune susceptibility 1. [provided by RefSeq, Nov 2008],

• 功能：
• disease:Defects in FOXD3 are associated with susceptibility to autoimmune disease type 1 (AIS1) [MIM:607836]; also called vitiligo-associated multiple autoimmune disease susceptibility type 2 (VAMAS2). Generalized vitiligo is an acquired disorder in which white patches of skin and hair result from autoimmune loss of melanocytes, often associated with other autoimmune disorders. Most cases occur in a sporadic family pattern suggesting polygenic, multifactorial inheritance. However, a striking family in which a somewhat unusual vitiligo phenotype has been described, characterized by progressively coalescent diffuse depigmentation and relatively early disease onset, segregated as an apparent autosomal dominant with incomplete penetrance.,function:Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promote

• 细胞定位：
• Nucleus .

• 组织表达：
• Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined.

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