Arrestin-β-2 Monoclonal Antibody
- 货号：YM1012
- 应用：WB;IF
- 种属：Human;Mouse;Rat;Pig
- 简介：
- >>MAPK signaling pathway;>>Chemokine signaling pathway;>>Endocytosis;>>Hedgehog signaling pathway;>>Dopaminergic synapse;>>Olfactory transduction;>>Relaxin signaling pathway;>>Parathyroid hormone synthesis, secretion and action;>>GnRH secretion;>>Morphine addiction;>>Chemical carcinogenesis - receptor activation
- 免疫原：
- Purified recombinant human Arrestin-β-2 (C-terminus) protein fragments expressed in E.coli.
- 特异性：
- Arrestin-β-2 Monoclonal Antibody detects endogenous levels of Arrestin-β-2 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 稀释：
- WB 1:1000 - 1:2000. IF 1:100 - 1:500. Not yet tested in other applications.
- 纯化工艺：
- Affinity purification
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- ARRB2;ARB2;ARR2;Beta-arrestin-2;Arrestin beta-2
- 背景：
- Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012],
- 功能：
- function:Regulates beta-adrenergic receptor function. Beta-arrestins seem to bind phosphorylated beta-adrenergic receptors, thereby causing a significant impairment of their capacity to activate G(S) proteins.,online information:Arrestin entry,similarity:Belongs to the arrestin family.,
- 细胞定位：
- Cytoplasm. Nucleus. Cell membrane. Membrane, clathrin-coated pit . Cytoplasmic vesicle. Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs.
- 组织表达：
- Brain,Cord blood,Endometrium,Muscle,Pancreas,Testis,Thyroid,
- Western Blot analysis using Arrestin-β-2 Monoclonal Antibody against HepG2 cell lysate.
- Immunofluorescence analysis of HeLa cells using Arrestin-β-2 Monoclonal Antibody.
