• 靶点：
• Ku-80

• 简介：
• >>Non-homologous end-joining

• 基因名称：
• xrcc5

• Human Gene Id：
• 7520

• Human Swiss Prot No：
• P13010

• Mouse Swiss Prot No：
• P27641

• 免疫原：
• Purified recombinant human Ku80 protein fragments expressed in E.coli

• 特异性：
• This antibody detects endogenous levels of Ku80 and does not cross-react with related proteins.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Monoclonal, Mouse

• 稀释：
• wb dilution 1:1000 icc dilution 1:400 ip dilution 1:100. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• ATP dependent DNA helicase II 80 kDa subunit;ATP dependent DNA helicase II 86 Kd subunit;ATP dependent DNA helicase II;ATP-dependent DNA helicase 2 subunit 2;ATP-dependent DNA helicase II 80 kDa subunit;CTC box binding factor 85 kDa;CTC box-binding factor 85 kDa subunit;CTC85;CTCBF;DNA repair protein XRCC5;Double strand break rejoining;FLJ39089;G22P2;KARP 1;KARP1;Ku 80;Ku autoantigen 80kDa;Ku80;Ku86;Ku86 autoantigen related protein 1;KUB 2;KUB2;Lupus Ku autoantigen protein p86;NFIV;Nuclear factor IV;Thyroid lupus autoantigen;Thyroid-lupus autoantigen;TLAA;X ray repair complementing defective repair in Chinese hamster cells 5 (double strand break rejoining);X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining);X-ray repair cross-complementing protein 5;Xray repair complementing defective repair in Chinese hamster cells 5;XRCC 5;XRCC5;XRCC5_HUMAN.

• 实测条带：
• 86kD

• 背景：
• The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008],

• 功能：
• developmental stage:Expression increases during promyelocyte differentiation.,disease:Individuals with systemic lupus erythematosus (SLE) and related disorders produce extremely large amounts of autoantibodies to p70 and p86.,domain:The EEXXXDDL motif is required for the interaction with catalytic subunit PRKDC and its recruitment to sites of DNA damage.,function:Single stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by p70. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The Ku p70/p86 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of t

• 细胞定位：
• Nucleus . Nucleus, nucleolus . Chromosome .

• 组织表达：
• Cervix carcinoma,Coronary artery,Heart,Neuroblastoma,Osteoblast,Thy

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