Uroplakin III (ABT-UPK3) mouse mAb

    • 货号:YM6138
    • 应用:IHC;IF;WB;ELISA
    • 种属:Human;Mouse
      • 靶点:
      • Uroplakin III
      • 简介:
      • >>Bladder cancer
      • 基因名称:
      • UPK3A UPK3
      • 蛋白名称:
      • Uroplakin-3a (UP3a) (Uroplakin III) (UPIII)
      • Human Gene Id:
      • 7380
      • Human Swiss Prot No:
      • O75631
      • 免疫原:
      • Synthesized peptide derived from human Uroplakin III AA range: 200-287
      • 特异性:
      • This antibody detects endogenous levels of human Uroplakin III. Heat-induced epitope retrieval (HIER) TRIS-EDTA of pH8.0 was highly recommended as antigen repair method in paraffin section
      • 组成:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • 来源:
      • Mouse, Monoclonal/IgG1, Lambda
      • 稀释:
      • WB 1:500-2000, IHC-p 1:200-400, IF 1:50-200, ELISA 1:5000-20000
      • 纯化工艺:
      • The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
      • 储存:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • 分子量:
      • 31kD
      • 背景:
      • This gene encodes a member of the uroplakin family, a group of transmembrane proteins that form complexes on the apical surface of the bladder epithelium. Mutations in this gene may be associated with renal adysplasia. Alternatively spliced transcript variants have been described.[provided by RefSeq, Nov 2009],
      • 功能:
      • disease:Defects in UPK3A are a cause of renal adysplasia [MIM:191830]; also known as renal agenesis or renal aplasia. Renal agenesis refers to the absence of one (unilateral) or both (bilateral) kidneys at birth. Bilateral renal agenesis belongs to a group of perinatally lethal renal diseases, including severe bilateral renal dysplasia, unilateral renal agenesis with contralateral dysplasia and severe obstructive uropathy.,function:Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence.,similarity:Belongs to the uroplakin-3 family.,subcellular location:Heterodimer formation
      • 细胞定位:
      • Membranous, Cytoplasmic
      • 组织表达:
      • Expressed in ureter.
      • 产品图片
      • Human bladder tissue was stained with Anti-Uroplakin III (ABT-UPK3) Antibody
      • Whole cell lysates were separated by 15% SDS-PAGE, and the membrane was blotted with anti-Uroplakin III (ABT-UPK3) antibody. The HRP-conjugated Goat anti-Mouse IgG(H + L) antibody was used to detect the antibody. Lane 1: Mouse bladder Predicted band size: 30kDa Observed band size: 50-60kDa Non-specific band: 55kd, heavy chain of antibody in mouse bladder tissue