GABA A Receptor α4 Polyclonal Antibody
- 货号:YN5593
- 应用:WB;IHC;IF
- 种属:Human;Rat;Mouse
- 简介:
- >>Neuroactive ligand-receptor interaction;>>Retrograde endocannabinoid signaling;>>GABAergic synapse;>>Taste transduction;>>Morphine addiction;>>Nicotine addiction
- 蛋白名称:
- Gamma-aminobutyric acid receptor subunit alpha-4 (GABA(A) receptor subunit alpha-4)
- 免疫原:
- Synthetic Peptide of GABA A Receptor α4 AA range: 149-199
- 特异性:
- GABA A Receptor α4 protein(A226) detects endogenous levels of GABA A Receptor α4
- 组成:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源:
- Polyclonal, Rabbit,IgG
- 稀释:
- WB 1:1000-2000, IHC 1:100-200. IF 1:50-200
- 纯化工艺:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称:
- GABRA4;Gamma-aminobutyric acid receptor subunit alpha-4;GABA(A) receptor subunit alpha-4
- 背景:
- Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.[provided by RefSeq, Feb 2011],
- 功能:
- function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.,induction:The alpha4 beta2 gamma 2L receptor is not repressed by diazepam.,online information:Forbidden fruit - Issue 56 of March 2005,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.,
- 细胞定位:
- Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
- 组织表达:
- Brain,Brain cortex,
![](/uploadfiles/PIC/ym3552-gaba-a-receptor-a4-01.jpg)
- Western blot analysis of 1) Mouse Brain Tissue, 2)Rat Brain Tissue with GABA A Receptor α4 Rabbit pAb diluted at 1:2,000.
![](/uploadfiles/PIC/ym3552-gaba-a-receptor-a4-02.jpg)
- Immunohistochemical analysis of paraffin-embedded Rat BrainTissue using GABA A Receptor α4 Rabbit pAb diluted at 1:200.
![](/uploadfiles/PIC/ym3552-gaba-a-receptor-a4-03.jpg)
- Immunohistochemical analysis of paraffin-embedded Mouse BrainTissue using GABA A Receptor α4 Rabbit pAb diluted at 1:200.