• 靶点：
• LBP

• 简介：
• >>NF-kappa B signaling pathway;>>Toll-like receptor signaling pathway;>>Alcoholic liver disease;>>Tuberculosis;>>Lipid and atherosclerosis

• 基因名称：
• LBP

• 蛋白名称：
• Lipopolysaccharide-binding protein

• Human Gene Id：
• 3929

• Human Swiss Prot No：
• P18428

• Mouse Gene Id：
• 16803

• Mouse Swiss Prot No：
• Q61805

• Rat Swiss Prot No：
• Q63313

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human LBP. AA range:221-270

• 特异性：
• LBP Polyclonal Antibody detects endogenous levels of LBP protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• LBP;Lipopolysaccharide-binding protein;LBP

• 实测条带：
• 53kD

• 背景：
• lipopolysaccharide binding protein(LBP) Homo sapiens The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). [provided by RefSeq, Apr 2012],

• 功能：
• function:Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. The LBP/LPS complex seems to interact with the CD14 receptor.,similarity:Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.,

• 细胞定位：
• Secreted . Cytoplasmic granule membrane . Membrane-associated in polymorphonuclear Leukocytes (PMN) granules. .

• 组织表达：
• Detected in blood serum (at protein level).

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