• 靶点：
• LSP1

• 简介：
• >>C-type lectin receptor signaling pathway;>>Tuberculosis

• 基因名称：
• LSP1

• 蛋白名称：
• Lymphocyte-specific protein 1

• Human Gene Id：
• 4046

• Human Swiss Prot No：
• P33241

• Mouse Swiss Prot No：
• P19973

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human LSP1. AA range:104-153

• 特异性：
• LSP1 Polyclonal Antibody detects endogenous levels of LSP1 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• LSP1;WP34;Lymphocyte-specific protein 1;47 kDa actin-binding protein;52 kDa phosphoprotein;pp52;Lymphocyte-specific antigen WP34

• 实测条带：
• 37kD

• 背景：
• This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],

• 功能：
• function:May play a role in mediating neutrophil activation and chemotaxis.,PTM:Phosphorylated by casein kinase II, protein kinase C and MAPKAPK2. Phosphorylation by PKC induces translocation from membrane to cytoplasm. Phosphorylation by MAPKAPK2 may regulate neutrophil chemotaxis.,subunit:Binds actin.,tissue specificity:Activated T-lymphocytes.,

• 细胞定位：
• Cell membrane; Peripheral membrane protein; Cytoplasmic side.

• 组织表达：
• Activated T-lymphocytes.

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