• 靶点：
• CXCR-3

• 简介：
• >>Cytokine-cytokine receptor interaction;>>Viral protein interaction with cytokine and cytokine receptor;>>Chemokine signaling pathway

• 基因名称：
• CXCR3

• 蛋白名称：
• C-X-C chemokine receptor type 3

• Human Gene Id：
• 2833

• Human Swiss Prot No：
• P49682

• Mouse Gene Id：
• 12766

• Mouse Swiss Prot No：
• O88410

• Rat Gene Id：
• 84475

• Rat Swiss Prot No：
• Q9JII9

• 免疫原：
• The antiserum was produced against synthesized peptide derived from the Internal region of human CXCR3. AA range:161-210

• 特异性：
• CXCR-3 Polyclonal Antibody detects endogenous levels of CXCR-3 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CXCR3;GPR9;C-X-C chemokine receptor type 3;CXC-R3;CXCR-3;CKR-L2;G protein-coupled receptor 9;Interferon-inducible protein 10 receptor;IP-10 receptor;CD183

• 实测条带：
• 37kD

• 背景：
• C-X-C motif chemokine receptor 3(CXCR3) Homo sapiens This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011],

• 功能：
• function:Receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC). Isoform 2 is a receptor for CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the growth of human microvascular endothelial cells (HMVEC). Isoform 2 may play a role in angiogenesis. Isoform 3 mediates activity of CXCL11.,online information:CXC chemokine receptors entry,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta.,

• 细胞定位：
• [Isoform 1]: Cell membrane ; Multi-pass membrane protein .; [Isoform 2]: Cell membrane ; Multi-pass membrane protein .

• 组织表达：
• Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta. Isoform 2 is expressed in endothelial cells. Expressed in T-cells (at protein level).

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