CD85c Polyclonal Antibody
- 货号：YT5510
- 应用：WB;IHC;IF;ELISA
- 种属：Human
- 简介：
- >>Osteoclast differentiation;>>B cell receptor signaling pathway
- 蛋白名称：
- Leukocyte immunoglobulin-like receptor subfamily B member 5
- 免疫原：
- The antiserum was produced against synthesized peptide derived from the N-terminal region of human LILRB5. AA range:21-70
- 特异性：
- CD85c Polyclonal Antibody detects endogenous levels of CD85c protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- LILRB5;LIR8;Leukocyte immunoglobulin-like receptor subfamily B member 5;CD85 antigen-like family member C;Leukocyte immunoglobulin-like receptor 8;LIR-8;CD85c
- 背景：
- This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Several other LIR subfamily B receptors are expressed on immune cells where they bind to MHC class I molecules on antigen-presenting cells and inhibit stimulation of an immune response. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
- 功能：
- domain:Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.,function:May act as receptor for class I MHC antigens.,similarity:Contains 4 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Detected in a natural killer (NK) cells.,
- 细胞定位：
- Membrane; Single-pass type I membrane protein.
- 组织表达：
- Detected in a natural killer (NK) cells.
- Western Blot analysis of HepG2 cells using CD85c Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
- Immunohistochemical analysis of paraffin-embedded human-spleen, antibody was diluted at 1:100
