Total CBP 35 Cell-Based Colorimetric ELISA Kit
- Catalog No.:KA3270C
- Applications:ELISA
- Reactivity:Human;Mouse;Rat
- Gene Name:
- LGALS3
- Human Gene Id:
- 3958
- Human Swiss Prot No:
- P17931
- Mouse Swiss Prot No:
- P16110
- Rat Swiss Prot No:
- P08699
- Storage Stability:
- 2-8°C/6 months
- Other Name:
- Galectin-3 (Gal-3) (35 kDa lectin) (Carbohydrate-binding protein 35) (CBP 35) (Galactose-specific lectin 3) (Galactoside-binding protein) (GALBP) (IgE-binding protein) (L-31) (Laminin-binding protein) (Lectin L-29) (Mac-2 antigen)
- Detection Method:
- Colorimetric
- Background:
- function:Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis.,online information:Galectin-3,similarity:Contains 1 galectin domain.,subcellular location:Cytoplasmic in adenomas and carcinomas. May be secreted by a non-classical secretory pathway and associate with the cell surface.,subunit:Probably forms homo- or heterodimers. Interacts with DMBT1 (By similarity). Forms a complex with the ITGA3, ITGB1 and CSPG4. Interacts with LGALS3BP, LYPD3, CYHR1 and UACA.,tissue specificity:A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages.,
- Function:
- skeletal system development, extracellular matrix organization, extracellular structure organization,
- Subcellular Location:
- Cytoplasm . Nucleus. Secreted . Secreted by a non-classical secretory pathway and associates with the cell surface. Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059). .
- Expression:
- A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages. Expressed in fetal membranes.
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