SPHK2 Mouse mAb(7A5)

  • Catalog No.：YM3806
  • Applications：WB;IHC
  • Reactivity：Human;Mouse;Rat
    • Target：
    • SphK2
    • Gene Name：
    • SPHK2
    • Protein Name：
    • SPHK2
    • Human Swiss Prot No：
    • Q9NRA0
    • Mouse Swiss Prot No：
    • Q9JIA7
    • Immunogen：
    • Synthesized peptide derived from human SPHK2
    • Specificity：
    • This antibody detects endogenous levels of SPHK2 at Human, Mouse,Rat
    • Formulation：
    • Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
    • Source：
    • Mouse,monoclonal
    • Dilution：
    • WB 1:500-2000 IHC 1:50-200
    • Purification：
    • The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • Sphingosine kinase 2 (SK 2) (SPK 2) (EC 2.7.1.91)
    • Molecular Weight(Da)：
    • 72kD
    • Function：
    • alternative products:Experimental confirmation may be lacking for some isoforms,catalytic activity:ATP + sphinganine = ADP + sphinganine 1-phosphate.,catalytic activity:ATP + sphingosine = ADP + sphingosine 1-phosphate.,cofactor:Magnesium.,function:Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra-and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine.,similarity:Contains 1 DAGKc domain.,
    • Subcellular Location：
    • Cytoplasm . Nucleus . Endoplasmic reticulum . Mitochondrion inner membrane . In nucleus, located in nucleosomes where it associates with core histone proteins such as histone 3 (PubMed:19729656). In brains of patients with Alzheimer's disease, may be preferentially localized in the nucleus. Cytosolic expression decrease correlates with the density of amyloid deposits (PubMed:29615132). In apoptotic cells, colocalizes with CASP1 in cell membrane where is cleaved and released from cells in an active form (PubMed:20197547). .; [Isoform 2]: Lysosome membrane .
    • Expression：
    • Mainly expressed in adult kidney, liver, and brain (PubMed:10751414). Expressed in cerebral cortex and hippocampus (at protein level) (PubMed:29615132). Isoform 1 is the predominant form expressed in most tissues (PubMed:16103110).

    Attributes

    • Code：
    • YM3806
    • Size
    • 40μL / 100μL / 200μL
    • Price$：
    • 160 / 280 / 450
    • Delivery：
    • 2024-04-26
    Order

    Related Products