Claudin 2 (PT0311) Mouse mAb

    • Catalog No.:YM4159
    • Applications:WB;IHC;ELISA
    • Reactivity:Human
      • Target:
      • Claudin-2
      • Fields:
      • >>Cell adhesion molecules;>>Tight junction;>>Leukocyte transendothelial migration;>>Pathogenic Escherichia coli infection;>>Hepatitis C
      • Gene Name:
      • CLDN2 PSEC0059 SP82 UNQ705/PRO1356
      • Protein Name:
      • Claudin 2
      • Human Gene Id:
      • 9075
      • Human Swiss Prot No:
      • P57739
      • Immunogen:
      • Synthesized peptide derived from human Claudin 2 AA range: 150-250
      • Specificity:
      • This antibody detects endogenous levels of human Claudin 2
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Mouse, Monoclonal/IgG2b, Kappa
      • Dilution:
      • IHC-p 1:100-300,WB 1:500-2000,ELISA 1:5000-20000
      • Purification:
      • The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
      • Storage Stability:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name:
      • Claudin-2 (SP82)
      • Molecular Weight(Da):
      • 25kD
      • Background:
      • This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.[provided by RefSeq, Jan 2010],
      • Function:
      • function:Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.,similarity:Belongs to the claudin family.,subunit:Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN1, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.,
      • Subcellular Location:
      • Cell junction, tight junction . Cell membrane ; Multi-pass membrane protein .
      • Expression:
      • Colon,Colon epithelium,Kidney,Skin,Teratocarcinoma,Thalamus,
      • Products Images
      • Human stomach tissue was stained with Anti-Claudin 2 (PT0311) Antibody
      • Whole cell lysates were separated by 10% SDS-PAGE, and the membrane was blotted with anti-Claudin 2 (PT0311) antibody. The HRP-conjugated Goat anti-Mouse IgG(H + L) antibody was used to detect the antibody. Lane 1: HCT116 Predicted band size: 29kDa Observed band size: 50kDa