T-bet (PTR1291) mouse mAb

  • Catalog No.：YM4701
  • Applications：WB;IF;ELISA
  • Reactivity：Human;Mouse;
    • Target：
    • TBX21
    • Gene Name：
    • TBX21 TBET TBLYM
    • Protein Name：
    • T-box transcription factor TBX21 (T-box protein 21) (T-cell-specific T-box transcription factor T-bet) (Transcription factor TBLYM)
    • Human Swiss Prot No：
    • Q9UL17
    • Mouse Swiss Prot No：
    • Q9JKD8
    • Immunogen：
    • Synthesized peptide derived from human T-bet. AA range: 100-200
    • Specificity：
    • This antibody detects endogenous levels of T-bet protein.
    • Formulation：
    • PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
    • Source：
    • Mouse, Monoclonal/IgG2a, kappa
    • Dilution：
    • WB 1:500-2000. IF 1:100-500. ELISA 1:1000-5000
    • Purification：
    • Protein G
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • T-box transcription factor TBX21 (T-box protein 21) (T-cell-specific T-box transcription factor T-bet) (Transcription factor TBLYM)
    • Molecular Weight(Da)：
    • 58kD
    • Observed Band(KD)：
    • 62kD
    • Background：
    • T-box 21(TBX21) Homo sapiens This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008],
    • Function：
    • Lineage-defining transcription factor which initiates Th1 lineage development from naive Th precursor cells both by activating Th1 genetic programs and by repressing the opposing Th2 and Th17 genetic programs . Activates transcription of a set of genes important for Th1 cell function, including those encoding IFN-gamma and the chemokine receptor CXCR3. Activates IFNG and CXCR3 genes in part by recruiting chromatin remodeling complexes including KDM6B, a SMARCA4-containing SWI/SNF-complex, and an H3K4me2-methyltransferase complex to their promoters and all of these complexes serve to establish a more permissive chromatin state conducive with transcriptional activation (By similarity). Can activate Th1 genes also via recruitment of Mediator complex and P-TEFb (composed of CDK9 and CCNT1/cyclin-T1) in the form of the super elongation complex (SEC) to super-enhancers and associated genes in
    • Subcellular Location：
    • Nuclear
    • Expression：
    • T-cell specific.

    Attributes

    • Code：
    • YM4701
    • Size
    • 40μL / 100μL / 200μL
    • Price$：
    • 160 / 280 / 450
    • Delivery：
    • 2024-09-19
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