PD-1 (PT1707) mouse mAb

    • Catalog No.:YM6084
    • Applications:IHC-p,IF(paraffin section)
    • Reactivity:Human,Mouse
      • Gene Name:
      • PDCD1 PD1
      • Protein Name:
      • Programmed cell death protein 1 (Protein PD-1) (hPD-1) (CD antigen CD279)
      • Human Gene Id:
      • 5133
      • Human Swiss Prot No:
      • Q15116
      • Immunogen:
      • Synthesized peptide derived from human PD-1
      • Specificity:
      • This antibody detects endogenous levels of human PD-1. Heat-induced epitope retrieval (HIER) Citrate buffer of pH6.0 was highly recommended as antigen repair method in paraffin section
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Mouse/IgG1, Kappa
      • Dilution:
      • WB 500-2000 IHC-p 1:100-500
      • Purification:
      • The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
      • Storage Stability:
      • -20°C/1 year
      • Background:
      • programmed cell death 1(PDCD1) Homo sapiens This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008],
      • Function:
      • developmental stage:Induced at programmed cell death.,disease:Genetic variation in PDCD1 is associated with susceptibility to systemic lupus erythematosus type 2 (SLEB2) [MIM:605218]. Systemic lupus erythematosus is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.,function:Possible cell death inducer, in association with other factors.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Monomer.,
      • Subcellular Location:
      • Membranous, Cytoplasmic
      • Expression:
      • Placenta,Pooled tissue,Uterine cervix,
      • Products Images
      • Immunohistochemical analysis of paraffin-embedded Tonsil. 1, Antibody was diluted at 1:200(4° overnight). 2, Citric acid ,pH6.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).
      • Immunohistochemical analysis of paraffin-embedded Tonsil. 1, Antibody was diluted at 1:200(4° overnight). 2, Citric acid ,pH6.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).