BC11B Polyclonal Antibody

  • Catalog No.：YN1700
  • Applications：WB;ELISA
  • Reactivity：Human;Mouse
    • Target：
    • BC11B
    • Fields：
    • >>Transcriptional misregulation in cancer
    • Gene Name：
    • BCL11B CTIP2 RIT1
    • Protein Name：
    • B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1)
    • Human Swiss Prot No：
    • Q9C0K0
    • Mouse Swiss Prot No：
    • Q99PV8
    • Immunogen：
    • Synthesized peptide derived from human protein . at AA range: 570-650
    • Specificity：
    • BC11B Polyclonal Antibody detects endogenous levels of protein.
    • Formulation：
    • Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • WB 1:500-2000 ELISA 1:5000-20000
    • Purification：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Observed Band(KD)：
    • 98kD
    • Background：
    • B-cell CLL/lymphoma 11B(BCL11B) Homo sapiens This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2013],
    • Function：
    • function:Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. May be a key regulator of both differentiation and survival during thymocyte development. Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element.,similarity:Contains 6 C2H2-type zinc fingers.,subunit:Interacts with TFCOUP1, SIRT1, ARP1 and EAR2.,tissue specificity:Highly expressed in brain and in malignant T-cell lines derived from patients with adult T-cell leukemia/lymphoma.,
    • Subcellular Location：
    • Nucleus .
    • Expression：
    • Highly expressed in brain and in malignant T-cell lines derived from patients with adult T-cell leukemia/lymphoma.

    Attributes

    • Code：
    • YN1700
    • Size
    • 40μL / 100μL / 200μL
    • Price$：
    • 150 / 280 / 450
    • Delivery：
    • 2024-12-23
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