GEF-H1 (phospho-Ser886) rabbit pAb

  • Catalog No.:YP1346
  • Applications:WB
  • Reactivity:Human,Mouse,Rat
    • Gene Name:
    • ARHGEF2 KIAA0651 LFP40
    • Protein Name:
    • GEF-H1 (Ser886)
    • Human Gene Id:
    • 9181
    • Human Swiss Prot No:
    • Q92974
    • Mouse Swiss Prot No:
    • Q60875
    • Immunogen:
    • Synthesized phosho peptide around human GEF-H1 (Ser886)
    • Specificity:
    • This antibody detects endogenous levels of Human Mouse Rat GEF-H1 (phospho-Ser886)
    • Formulation:
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source:
    • Rabbit
    • Dilution:
    • WB 1:1000-2000
    • Purification:
    • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
    • Concentration:
    • 1 mg/ml
    • Storage Stability:
    • -20°C/1 year
    • Other Name:
    • Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40)
    • Observed Band(KD):
    • 111
    • Background:
    • Rho/Rac guanine nucleotide exchange factor 2(ARHGEF2) Homo sapiens Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009],
    • Function:
    • domain:The DH (DBL-homology) domain interacts with and promotes loading of GTP on RhoA.,domain:The PH (pleckstrin-homology) domain is involved in microtubule binding and targeting to tight junctions.,function:Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases.,online information:ARHGEF2 entry,PTM:Phosphorylation of Ser-886 by PAK1 induces binding to protein 14-3-3 zeta, promoting its relocation to microtubules and the inhibition of its activit
    • Subcellular Location:
    • intracellular,cytoplasm,Golgi apparatus,spindle,cytosol,cytoskeleton,microtubule,bicellular tight junction,focal adhesion,postsynaptic density,cytoplasmic, membrane-bounded vesicle,cytoplasmic vesicle,
    • Expression:
    • Brain,Cervix carcinoma,Epithelium,Platelet,