FER (Phospho Tyr714) Rabbit pAb
- Catalog No.:YP1865
- Applications:IHC;WB
- Reactivity:Human;Mouse;Rat
- Target:
- FER
- Fields:
- >>Adherens junction
- Gene Name:
- FER TYK3
- Protein Name:
- Tyrosine-protein kinase Fer (EC 2.7.10.2) (Feline encephalitis virus-related kinase FER) (Fujinami poultry sarcoma/Feline sarcoma-related protein Fer) (Proto-oncogene c-Fer) (Tyrosine kinase 3) (p94-F
- Sequence:
- P16591
- Human Gene Id:
- 2241
- Human Swiss Prot No:
- P16591
- Mouse Gene Id:
- 14158
- Mouse Swiss Prot No:
- P70451
- Rat Swiss Prot No:
- P09760
- Immunogen:
- Synthesized peptide derived from human FER (Phospho Tyr714)
- Specificity:
- This antibody detects endogenous levels of FER (Phospho Tyr714) Rabbit pAb at Human, Mouse,Rat
- Formulation:
- Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
- Source:
- Rabbit,polyclonal
- Dilution:
- WB 1:500-2000 IHC 1:50-200
- Purification:
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Other Name:
- Tyrosine-protein kinase Fer (EC 2.7.10.2) (Feline encephalitis virus-related kinase FER) (Fujinami poultry sarcoma/Feline sarcoma-related protein Fer) (Proto-oncogene c-Fer) (Tyrosine kinase 3) (p94-Fer)
- Observed Band(KD):
- 85kD
- Background:
- FER tyrosine kinase(FER) Homo sapiens The protein encoded by this gene is a member of the FPS/FES family of non-transmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Apr 2015],
- Function:
- catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Tyrosine kinase of the non-receptor type. Probably performs an important function, perhaps in regulatory processes such as cell cycle control.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.,similarity:Contains 1 FCH domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,subcellular location:Associated with the chromatin.,tissue specificity:Expressed in a variety of lymphoid cell lines.,
- Subcellular Location:
- Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Cell junction. Membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm, cell cortex. Associated with the chromatin. Detected on microtubules in polarized and motile vascular endothelial cells. Colocalizes with F-actin at the cell cortex. Colocalizes with PECAM1 and CTNND1 at nascent cell-cell contacts.
- Expression:
- Isoform 1 is detected in normal colon and in fibroblasts (at protein level). Isoform 3 is detected in normal testis, in colon carcinoma-derived metastases in lung, liver and ovary, and in colon carcinoma and hepato carcinoma cell lines (at protein level). Isoform 3 is not detected in normal colon or in normal fibroblasts (at protein level). Widely expressed.
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- Antibody-FAQs
- Products Images
- Western Blot analysis of A431 mouse heart using primary antibody at 1:1000 dilution 4°C, overnight. Secondary antibody(catalog#:RS23920) was diluted at 1:10000 25°C,1.5hours