PFK-2 car (Phospho Ser466) Rabbit pAb
- Catalog No.:YP1872
- Applications:IHC;WB
- Reactivity:Human;Mouse;Rat
- Target:
- PFK-2 car
- Fields:
- >>Fructose and mannose metabolism;>>Metabolic pathways;>>AMPK signaling pathway;>>Thyroid hormone signaling pathway
- Gene Name:
- PFKFB2
- Protein Name:
- 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (6PF-2-K/Fru-2,6-P2ase 2) (PFK/FBPase 2) (6PF-2-K/Fru-2,6-P2ase heart-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-
- Sequence:
- O60825
- Human Gene Id:
- 5208
- Human Swiss Prot No:
- O60825
- Mouse Gene Id:
- 18640
- Mouse Swiss Prot No:
- P70265
- Rat Gene Id:
- 24640
- Rat Swiss Prot No:
- Q9JJH5
- Immunogen:
- Synthesized peptide derived from human PFKFB2 (Phospho Ser466)
- Specificity:
- This antibody detects endogenous levels of PFKFB2 (Phospho Ser466) Rabbit pAb at Human, Mouse,Rat
- Formulation:
- Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
- Source:
- Rabbit,polyclonal
- Dilution:
- WB 1:500-2000 IHC 1:50-200
- Purification:
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Other Name:
- 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (6PF-2-K/Fru-2,6-P2ase 2) (PFK/FBPase 2) (6PF-2-K/Fru-2,6-P2ase heart-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105);Fructose-2,6-bisphosphatase (EC 3.1.3.46)]
- Observed Band(KD):
- 58kD
- Background:
- 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2(PFKFB2) Homo sapiens The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
- Function:
- catalytic activity:ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate.,catalytic activity:Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.,enzyme regulation:Phosphorylation results in the activation of the kinase activity.,function:Synthesis and degradation of fructose 2,6-bisphosphate.,similarity:In the C-terminal section; belongs to the phosphoglycerate mutase family.,subunit:Homodimer.,tissue specificity:Heart.,
- Expression:
- Heart.
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- Antibody-FAQs
- Products Images
- Western Blot analysis of K562 Mouse brain using primary antibody at 1:1000 dilution 4°C, overnight. Secondary antibody(catalog#:RS23920) was diluted at 1:10000 25°C,1.5hours