• Target：
• CAR

• Fields：
• >>Viral myocarditis

• Gene Name：
• CXADR

• Protein Name：
• Coxsackievirus and adenovirus receptor

• Human Gene Id：
• 1525

• Human Swiss Prot No：
• P78310

• Mouse Gene Id：
• 13052

• Mouse Swiss Prot No：
• P97792

• Rat Gene Id：
• 89843

• Rat Swiss Prot No：
• Q9R066

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human CXADR. AA range:1-50

• Specificity：
• CAR Polyclonal Antibody detects endogenous levels of CAR protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CXADR;CAR;Coxsackievirus and adenovirus receptor;CAR;hCAR;CVB3-binding protein;Coxsackievirus B-adenovirus receptor;HCVADR

• Observed Band(KD)：
• 40kD

• Background：
• The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Several transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene are found on chromosomes 15, 18, and 21. [provided by RefSeq, May 2011],

• Function：
• domain:The Ig-like C2-type 1 domain probably mediates homodimerization and interaction with JAML.,domain:The PDZ-binding motif mediates interaction with MPDZ and BAIAP1.,function:Component of the epithelial apical junction complex that is essential for the tight junction integrity. Proposed to function as a homophilic cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1/JAML located in the plasma membrane of PMN.,PTM:N-glycosylated.,PTM:Palmitoylated on Cys-259 and/or Cys-260; required for proper localization to the plasma membrane.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subcellular location:In epithelial cells localizes to the apical junction complex composced of tight and adherens junctions. In airway epithelial ce

• Subcellular Location：
• [Isoform 1]: Cell membrane ; Single-pass type I membrane protein . Basolateral cell membrane ; Single-pass type I membrane protein . Cell junction, tight junction . Cell junction, adherens junction . In epithelial cells localizes to the apical junction complex composed of tight and adherens junctions (PubMed:12297051). In airway epithelial cells localized to basolateral membrane but not to apical surface (PubMed:11316797). .; [Isoform 3]: Secreted .; [Isoform 4]: Secreted .; [Isoform 5]: Secreted .

• Expression：
• Expressed in pancreas, brain, heart, small intestine, testis, prostate and at a lower level in liver and lung. Isoform 5 is ubiquitously expressed. Isoform 3 is expressed in heart, lung and pancreas. In skeletal muscle, isoform 1 is found at the neuromuscular junction and isoform 2 is found in blood vessels. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. In heart expressed in subendothelial layers of the vessel wall but not in the luminal endothelial surface. Expression is elevated in hearts with dilated cardiomyopathy.

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