• Target：
• Protocadherin-11

• Gene Name：
• PCDH11X/PCDH11Y

• Protein Name：
• Protocadherin-11 X/Y-linked

• Human Gene Id：
• 83259/27328

• Human Swiss Prot No：
• Q9BZA8/Q9BZA7

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human PCDH-X/Y. AA range:531-580

• Specificity：
• Protocadherin-11 Polyclonal Antibody detects endogenous levels of Protocadherin-11 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• PCDH11Y;PCDH11;PCDH22;PCDHY;Protocadherin-11 Y-linked;Protocadherin-11;Protocadherin on the Y chromosome;PCDH-Y;Protocadherin prostate cancer;Protocadherin-PC;Protocadherin-22;PCDH11X;KIAA1326;PCDH11;PCDHX;Protocadherin-11 X-

• Molecular Weight(Da)：
• 147kD

• Background：
• This gene belongs to the protocadherin family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing seven cadherin repeats, a transmembrane domain, and a cytoplasmic tail that differs from those of the classical cadherins. This gene is located on the Y chromosome in a block of X/Y homology and is very closely related to its paralog on the X chromosome. The protein is thought to play a role in cell-cell recognition during development of the central nervous system. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013],

• Function：
• alternative products:Additional isoforms seem to exist,disease:A chromosomal aberration involving PCDH11Y is a cause of multiple congenital abnormalities, including severe bilateral vesicoureteral reflux (VUR) with ureterovesical junction defects. Translocation t(Y;3)(p11;p12) with ROBO2.,function:Potential calcium-dependent cell-adhesion protein.,similarity:Contains 7 cadherin domains.,subunit:Interacts with CTNNB1.,tissue specificity:Expressed strongly in fetal brain and brain (cortex, amygdala, thalamus, substantia nigra, hippocampus, caudate nucleus and corpus callosum). Expressed at low level in testis. Expressed in apoptosis-resistant cells.,

• Subcellular Location：
• Cell membrane ; Single-pass type I membrane protein .

• Expression：
• Expressed strongly in fetal brain and brain (cortex, amygdala, thalamus, substantia nigra, hippocampus, caudate nucleus and corpus callosum). Expressed at low level in testis. Expressed in apoptosis-resistant cells.

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