• Target：
• SR-7

• Fields：
• >>Ras signaling pathway;>>Calcium signaling pathway;>>Neuroactive ligand-receptor interaction;>>Serotonergic synapse

• Gene Name：
• HTR7

• Protein Name：
• 5-hydroxytryptamine receptor 7

• Human Gene Id：
• 3363

• Human Swiss Prot No：
• P34969

• Mouse Gene Id：
• 15566

• Mouse Swiss Prot No：
• P32304

• Rat Gene Id：
• 65032

• Rat Swiss Prot No：
• P32305

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human HTR7. AA range:391-440

• Specificity：
• SR-7 Polyclonal Antibody detects endogenous levels of SR-7 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• HTR7;5-hydroxytryptamine receptor 7;5-HT-7;5-HT7;5-HT-X;Serotonin receptor 7

• Molecular Weight(Da)：
• 54kD

• Background：
• The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders. Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends. [provided by RefSeq, Jul 2008],

• Function：
• alternative products:Isoform A and isoform B appear to be expressed at higher levels,function:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Isoform A is the predominant isoform in spleen, caudate and hippocampus. Isoform B is expressed at lower levels, and isoform D is a minor isoform.,

• Subcellular Location：
• Cell membrane; Multi-pass membrane protein.

• Expression：
• Isoform A is the predominant isoform in spleen, caudate and hippocampus. Isoform B is expressed at lower levels. Isoform D is a minor isoform in terms of expression.

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