• Target：
• Thrombospondin 4

• Fields：
• >>Phagosome;>>PI3K-Akt signaling pathway;>>Focal adhesion;>>ECM-receptor interaction;>>Malaria;>>Human papillomavirus infection

• Gene Name：
• THBS4

• Protein Name：
• Thrombospondin-4

• Human Gene Id：
• 7060

• Human Swiss Prot No：
• P35443

• Mouse Swiss Prot No：
• Q9Z1T2

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human THBS4. AA range:561-610

• Specificity：
• Thrombospondin 4 Polyclonal Antibody detects endogenous levels of Thrombospondin 4 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:100-500;IF ICC 1:100-500;ELISA 1:5000-20000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• THBS4;TSP4;Thrombospondin-4

• Molecular Weight(Da)：
• 106kD

• Background：
• thrombospondin 4(THBS4) Homo sapiens The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. It is involved in local signaling in the developing and adult nervous system, and it contributes to spinal sensitization and neuropathic pain states. This gene is activated during the stromal response to invasive breast cancer. It may also play a role in inflammatory responses in Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015],

• Function：
• function:Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen.,similarity:Belongs to the thrombospondin family.,similarity:Contains 1 TSP C-terminal (TSPC) domain.,similarity:Contains 1 TSP N-terminal (TSPN) domain.,similarity:Contains 4 EGF-like domains.,similarity:Contains 8 TSP type-3 repeats.,subunit:Homopentamer; disulfide-linked.,

• Subcellular Location：
• Endoplasmic reticulum . Sarcoplasmic reticulum . Secreted . Secreted, extracellular space . Secreted, extracellular space, extracellular matrix .

• Expression：
• Heart,PNS,Synovium,

THBS4/integrin α2 axis mediates BM-MSCs to promote angiogenesis in gastric cancer associated with chronic Helicobacter pylori infection. Aging-US Aging-Us. 2021 Aug 15; 13(15): 19375–19396 IF，IHC Mouse,Human Gastric mucosa

THBS4 promotes HCC progression by regulating ITGB1 via FAK/PI3K/AKT pathway. FASEB JOURNAL Faseb J. 2020 Aug;34(8):10668-10681 IHC Human 1:200 Liver tumor tissue,tumor adjacent tissue

He, LingNan, et al. "THBS4/Integrin α2 axis mediates BM-MSCs promote angiogenesis of gastric cancer associated with chronic Helicobacter pylori infection." (2021).

Wenshen Xiaozheng Tang alleviates fibrosis in endometriosis by regulating differentiation and paracrine signaling of endometrium-derived mesenchymal stem cells JOURNAL OF ETHNOPHARMACOLOGY Zhenzhen Zhang WB Human endometrium-derived mesenchymal stem cell (eMSC)

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