X11β Polyclonal Antibody

    • Catalog No.:YT4910
    • Applications:IHC;IF;WB;ELISA
    • Reactivity:Human;Mouse;Rat
      • Target:
      • X11β
      • Gene Name:
      • APBA2
      • Protein Name:
      • Amyloid beta A4 precursor protein-binding family A member 2
      • Human Gene Id:
      • 321
      • Human Swiss Prot No:
      • Q99767
      • Mouse Swiss Prot No:
      • P98084
      • Immunogen:
      • The antiserum was produced against synthesized peptide derived from human APBA2. AA range:371-420
      • Specificity:
      • X11β Polyclonal Antibody detects endogenous levels of X11β protein.
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Polyclonal, Rabbit,IgG
      • Dilution:
      • WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
      • Purification:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name:
      • APBA2;MINT2;X11L;Amyloid beta A4 precursor protein-binding family A member 2;Adapter protein X11beta;Neuron-specific X11L protein;Neuronal Munc18-1-interacting protein 2;Mint-2
      • Observed Band(KD):
      • 83kD
      • Background:
      • amyloid beta precursor protein binding family A member 2(APBA2) Homo sapiens The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
      • Function:
      • domain:Composed of an N-terminal domain that binds STXBP1, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the beta-amyloid precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane.,function:Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP.,similarity:Contains 1 PID domain.,similarity:Contains 2 PDZ (DHR) domains.,subunit:Part of a multimeric complex containing STXBP1 and syntaxin-1. Binds to the cytoplasmic domain of amyloid protein beta, and to the nuclear factor NF-kappa-B/p65 via its PDZ domain. Interacts with the amino-terminal domain of APBA2BP.,tissue specificity:Brain.,
      • Subcellular Location:
      • plasma membrane,synaptic vesicle,
      • Expression:
      • Brain.
      • Products Images
      • Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using APBA2 Antibody. The picture on the right is blocked with the synthesized peptide.