The specific immunogen used to produce this antibody is proprietary information.

Endogenous

PTGS2 COX2

Prostaglandin G/H synthase 2 (Cyclooxygenase-2) (COX-2) (PHS II) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (Prostaglandin-endoperoxide synthase 2)

Prostaglandin-endoperoxide synthase (PTGS) , also known as cyclooxygenase , is the key enzyme in prostaglandin biosynthesis , and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2 , which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events , suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq , Feb 2009] ,

Catalytic activity:Arachidonate + AH (2) + 2 O (2) = prostaglandin H (2) + A + H (2) O. ,cofactor:Binds 1 heme B (iron-protoporphyrin IX) group per subunit. ,Disease:Likely to play a role in inflammatory diseases such as rheumatoid arthritis. ,Function:May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity. ,induction:By cytokines and mitogens. ,miscellaneous:This enzyme acts both as a dioxygenase and as a peroxidase. ,miscellaneous:This enzyme is the target of nonsteroidal anti-inflammatory drugs such as aspirin. ,pathway:Lipid metabolism; prostaglandin biosynthesis. ,similarity:Belongs to the prostaglandin G/H synthase family. ,similarity:Contains 1 EGF-like domain. ,subunit:Homodimer. ,

Cytoplasm

>>Arachidonic acid metabolism ;
>>Metabolic pathways ;
>>NF-kappa B signaling pathway ;
>>VEGF signaling pathway ;
>>C-type lectin receptor signaling pathway ;
>>IL-17 signaling pathway ;
>>TNF signaling pathway ;
>>Retrograde endocannabinoid signaling ;
>>Serotonergic synapse ;
>>Ovarian steroidogenesis ;
>>Oxytocin signaling pathway ;
>>Regulation of lipolysis in adipocytes ;
>>Alzheimer disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Leishmaniasis ;
>>Human cytomegalovirus infection ;
>>Human papillomavirus infection ;
>>Kaposi sarcoma-associated herpesvirus infection ;
>>Pathways in cancer ;
>>Chemical carcinogenesis - DNA adducts ;
>>MicroRNAs in cancer ;
>>Small cell lung cancer