The antiserum was produced against synthesized peptide derived from human mTOR. AA range:2447-2496

mTOR Polyclonal Antibody detects endogenous levels of mTOR protein.

MTOR

Serine/threonine-protein kinase mTOR

MTOR ;
FRAP ;
FRAP1 ;
FRAP2 ;
RAFT1 ;
RAPT1 ;
Serine/threonine-protein kinase mTOR ;
FK506-binding protein 12-rapamycin complex-associated protein 1 ;
FKBP12-rapamycin complex-associated protein ;
Mammalian target of rapamycin ;
mTOR ;
Mechanistic tar

The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq , Sep 2008] ,

Function:Acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Part of the TORC2 complex which plays a critical role in AKT1 Ser-473 phosphorylation , and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization. ,similarity:Belongs to the PI3/PI4-kinase family. ,similarity:Contains 1 FAT domain. ,similarity:Contains 1 FATC domain. ,similarity:Contains 1 PI3K/PI4K domain. ,similarity:Contains 7 HEAT repeats. ,subunit:Interacts with the FKBP12-rapamycin complex. Binds UBQLN1. Forms part of the mammalian target of rapamycin 2 complex (TORC2) comprised of FRAP1 , GBL , PRR5 , RICTOR and SIN. TORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to PRR5 and RICTOR within the TORC2 complex. ,tissue specificity:Expressed in numerous tissues , with highest levels in testis. ,

Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side . Mitochondrion outer membrane ; Peripheral membrane protein ; Cytoplasmic side . Lysosome . Cytoplasm . Nucleus , PML body . Microsome membrane . Lysosome membrane . Cytoplasmic vesicle , phagosome . Shuttles between cytoplasm and nucleus. Accumulates in the nucleus in response to hypoxia (By similarity) . Targeting to lysosomes depends on amino acid availability and RRAGA and RRAGB (PubMed:18497260 , PubMed:20381137) . Lysosome targeting also depends on interaction with MEAK7. Translocates to the lysosome membrane in the presence of TM4SF5 (PubMed:30956113) . .

>>EGFR tyrosine kinase inhibitor resistance ;
>>Endocrine resistance ;
>>ErbB signaling pathway ;
>>HIF-1 signaling pathway ;
>>Phospholipase D signaling pathway ;
>>Autophagy - other ;
>>Autophagy - animal ;
>>mTOR signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>AMPK signaling pathway ;
>>Longevity regulating pathway ;
>>Longevity regulating pathway - multiple species ;
>>Cellular senescence ;
>>Apelin signaling pathway ;
>>Neutrophil extracellular trap formation ;
>>JAK-STAT signaling pathway ;
>>Th17 cell differentiation ;
>>Thermogenesis ;
>>Insulin signaling pathway ;
>>Thyroid hormone signaling pathway ;
>>Adipocytokine signaling pathway ;
>>Type II diabetes mellitus ;
>>Insulin resistance ;
>>Growth hormone synthesis , secretion and action ;
>>Alzheimer disease ;
>>Amyotrophic lateral sclerosis ;
>>Huntington disease ;
>>Spinocerebellar ataxia ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Shigellosis ;
>>Human cytomegalovirus infection ;
>>Human papillomavirus infection ;
>>Kaposi sarcoma-associated herpesvirus infection ;
>>Herpes simplex virus 1 infection ;
>>Human immunodeficiency virus 1 infection ;
>>Pathways in cancer ;
>>Proteoglycans in cancer ;
>>MicroRNAs in cancer ;
>>Chemical carcinogenesis - receptor activation ;
>>Colorectal cancer ;
>>Pancreatic cancer ;
>>Glioma ;
>>Prostate cancer ;
>>Acute myeloid leukemia ;
>>Breast cancer ;
>>Hepatocellular carcinoma ;
>>Gastric cancer ;
>>Central carbon metabolism in cancer ;
>>Choline metabolism in cancer ;
>>PD-L1 expression and PD-1 checkpoint pathway in cancer ;
>>Diabetic cardiomyopathy