The specific immunogen used to produce this antibody is proprietary information.

Endogenous

CDK4

Cyclin-dependent kinase 4

CDK4 ;
Cyclin-dependent kinase 4 ;
Cell division protein kinase 4 ;
PSK-J3

cyclin dependent kinase 4 (CDK4) Homo sapiens The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase , which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16 (INK4a) . This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb) . Mutations in this gene as well as in its related proteins including D-type cyclins , p16 (INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq , Jul 2008] ,

Catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,Disease:CDK4 mutations are involved in tumor formation. ,Disease:Defects in CDK4 are the cause of cutaneous malignant melanoma 3 (CMM3) [MIM:609048 , 155600]. Malignant melanoma is a malignant neoplasm of melanocytes , arising de novo or from a preexisting benign nevus , which occurs most often in the skin but also may involve other sites. ,enzyme regulation:Phosphorylation at Thr-172 is necessary for enzymatic activity. ,Function:Probably involved in the control of the cell cycle. ,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. ,similarity:Contains 1 protein kinase domain. ,subunit:Forms a stable complex with D-type G1 cyclins. Interacts with SEI1 and ZNF655/VIK. ,

Cytoplasm , Nucleus

>>Endocrine resistance ;
>>Cell cycle ;
>>p53 signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>Cellular senescence ;
>>Tight junction ;
>>T cell receptor signaling pathway ;
>>AGE-RAGE signaling pathway in diabetic complications ;
>>Cushing syndrome ;
>>Hepatitis C ;
>>Measles ;
>>Human cytomegalovirus infection ;
>>Influenza A ;
>>Human papillomavirus infection ;
>>Human T-cell leukemia virus 1 infection ;
>>Kaposi sarcoma-associated herpesvirus infection ;
>>Epstein-Barr virus infection ;
>>Pathways in cancer ;
>>Viral carcinogenesis ;
>>Pancreatic cancer ;
>>Glioma ;
>>Melanoma ;
>>Bladder cancer ;
>>Chronic myeloid leukemia ;
>>Small cell lung cancer ;
>>Non-small cell lung cancer ;
>>Breast cancer ;
>>Hepatocellular carcinoma