The specific immunogen used to produce this antibody is proprietary information.

Endogenous

CDK6 CDKN6

Cyclin-dependent kinase 6 (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE)

Cyclin-dependent kinase 6 ;
Cell division protein kinase 6 ;
Serine/threonine-protein kinase PLSTIRE ;

cyclin dependent kinase 6 (CDK6) Homo sapiens The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28 , and Schizosaccharomyces pombe cdc2 , and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase , which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase , as well as CDK4 , has been shown to phosphorylate , and thus regulate the activity of , tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants , encoding the same protein , have been identified. [provided by RefS

Catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,Function:Probably involved in the control of the cell cycle. Interacts with D-type G1 cyclins. ,polymorphism:Genetic variations in CDK6 influences stature as a quantitative trait type 11 (STQTL11) [MIM:612223]. Adult height is an easily observable and highly heritable complex continuous trait. Because of this , it is a model trait for studying genetic influence on quantitative traits. ,similarity:Belongs to the protein kinase superfamily. ,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. ,similarity:Contains 1 protein kinase domain. ,

Nuclear

>>Cell cycle ;
>>p53 signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>Cellular senescence ;
>>Cushing syndrome ;
>>Hepatitis C ;
>>Measles ;
>>Human cytomegalovirus infection ;
>>Influenza A ;
>>Human papillomavirus infection ;
>>Kaposi sarcoma-associated herpesvirus infection ;
>>Epstein-Barr virus infection ;
>>Pathways in cancer ;
>>Viral carcinogenesis ;
>>MicroRNAs in cancer ;
>>Pancreatic cancer ;
>>Glioma ;
>>Melanoma ;
>>Chronic myeloid leukemia ;
>>Small cell lung cancer ;
>>Non-small cell lung cancer ;
>>Breast cancer ;
>>Hepatocellular carcinoma