This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, is secreted by activated T cells and displays chemotactic activity for monocytes but not for neutrophils. It binds to the chemokine (C-C motif) receptor 8. [provided by RefSeq, Sep 2014],
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功能:
Function:Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8.,induction:By PMA.,online information:CCL1 entry,similarity:Belongs to the intercrine beta (chemokine CC) family.,subunit:Monomer.,
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细胞定位:
Secreted.
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组织表达:
Brain,
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研究领域:
>>Cytokine-cytokine receptor interaction ;
>>Viral protein interaction with cytokine and cytokine receptor ;
>>Chemokine signaling pathway