HIP1 Rabbit pAb
-YN6579
主要信息
Target
HIP1
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB
MW
114kD (Calculated)
Conjugate/Modification
Unmodified
货号: YN6579
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
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详细信息
推荐稀释比
WB 1:500-2000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
This antibody detects endogenous levels of HIP1 at Human, Mouse
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
理论分子量
114kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
Synthesized peptide derived from human HIP1
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特异性:
This antibody detects endogenous levels of HIP1 at Human, Mouse
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基因名称:
HIP1
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蛋白名称:
Huntingtin-interacting protein 1 (HIP-1) (Huntingtin-interacting protein I) (HIP-I)
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功能:
Plays a role in clathrin-mediated endocytosis and trafficking . Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner (By similarity). Regulates presynaptic nerve terminal activity (By similarity). Enhances androgen receptor (AR)-mediated transcription . May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway . Binds 3-phosphoinositides (via ENTH domain) . May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis . May play a functional role in the cell filament networks . May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors .
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细胞定位:
Cytoplasm. Nucleus. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Shuttles between cytoplasm and nucleus. Nuclear translocation can be induced by AR.
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组织表达:
Ubiquitously expressed with the highest level in brain. Expression is up-regulated in prostate and colon cancer.
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信号通路
文献引用（{{totalcount}}）
货号: YN6579
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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