The antiserum was produced against synthesized peptide derived from human PVRL4. AA range:312-361

Nectin 4 Polyclonal Antibody detects endogenous levels of Nectin 4 protein.

PVRL4

Poliovirus receptor-related protein 4

PVRL4 ;
LNIR ;
PRR4 ;
Poliovirus receptor-related protein 4 ;
Ig superfamily receptor LNIR ;
Nectin-4

This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011],

Function:Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with PVRL2/nectin-1. Does not act as receptor for alpha-herpesvirus entry into cells.,PTM:The soluble form is produced by proteolytic cleavage at the cell surface (shedding), probably by ADAM17/TACE.,similarity:Belongs to the nectin family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subcellular location:Colocalizes with MLLT4 at cadherin-based adherens junctions.,subcellular location:The secreted form is found in breast tumor patients.,subunit:Self-associates. Interacts via its Ig-like V-type domain with PVRL1/nectin-1 Ig-like V-type domain. Interacts via its C-terminus with MLLT4.,tissue specificity:Predominantly expressed in placenta. Not detected in normal breast epithelium but expressed in breast carcinoma.,

Cell membrane ; Single-pass type I membrane protein . Cell junction, adherens junction . Colocalizes with AFDN at cadherin-based adherens junctions (PubMed:11544254).; [Processed poliovirus receptor-related protein 4]: Secreted . The secreted form is found in breast tumor patients (PubMed:15784625).

Predominantly expressed in placenta. Not detected in normal breast epithelium but expressed in breast carcinoma.

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