Phospho PKC ζ (T410) Cell-Based Colorimetric ELISA Kit

  • 货号：KA1177C
  • 应用：ELISA
  • 种属：Human;Mouse;Rat
    • 基因名称：
    • PRKCZ
    • Human Gene Id：
    • 5590
    • Human Swiss Prot No：
    • Q05513
    • Mouse Swiss Prot No：
    • Q02956
    • 储存：
    • 2-8°C/6 months
    • 其他名称：
    • Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta)
    • 检测方法：
    • Colorimetric
    • 背景：
    • catalytic activity:ATP + a protein = ADP + a phosphoprotein.,domain:The C1 domain does not bind the diacylglycerol (DAG).,domain:The OPR domain mediates mutually exclusive interactions with SQSTM1 and PARD6B.,enzyme regulation:Phosphatidylinositol 3,4,5-trisphosphate might be a physiological activator. Two specific sites, Thr-410 (activation loop of the kinase domain) and Thr-560 (turn motif), need to be phosphorylated for its full activation.,function:PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. Subunit of a quaternary complex that plays a central role in epithelial cell polarization.,function:This is a calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 OPR domain.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 protein kinase domain.,subcellular location:In the retina, localizes in the terminals of the rod bipolar cells (By similarity). Associates with endosomes.,subunit:Forms a ternary complex with SQSTM1 and KCNAB2. Forms another ternary complex with SQSTM1 and GABRR3. Forms a complex with SQSTM1 and MAP2K5 (By similarity). Interacts with PARD6A, PARD6B, PARD6G and SQSTM1. Part of a complex with PARD3, PARD6A or PARD6B or PARD6G and CDC42 or RAC1. Interacts with ADAP1/CENTA1. Forms a ternary complex composed of SQSTM1 and PAWR. Interacts directly with SQSTM1 (Probable). Interacts with IKBKB.,tissue specificity:Expressed in brain, and to a lesser extent in lung, kidney and testis.,
    • 功能：
    • microtubule cytoskeleton organization, regulation of protein amino acid phosphorylation, negative regulation of protein amino acid phosphorylation, regulation of cell-matrix adhesion, positive regulation of cell-matrix adhesion,protein complex assembly, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, cellular ion homeostasis, anti-apoptosis, cytoskeleton organization, microtubule-based process, microtubule-based movement, cell surface receptor linked signal transduction, intracellular signaling cascade, behavior, learning or memory, memory, long-term memory, positive regulation of cell proliferation, negative regulation of signal transduction, regulation of phospholipase activity, positive regulation of phospholipase activity, negative regulation of phosphorus metabolic process, negative regulation of macromolecule metabolic process, positiv
    • 细胞定位：
    • Cytoplasm . Endosome . Cell junction . Membrane ; Peripheral membrane protein . In the retina, localizes in the terminals of the rod bipolar cells (By similarity). Associates with endosomes (PubMed:9566925). Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction (PubMed:7597083). Colocalizes with VAMP2 and WDFY2 in intracellular vesicles (PubMed:17313651). Transiently translocates to the membrane of CA1 hippocampal cells in response to the induction of long term potentiation (By similarity). .; [Isoform 2]: Cytoplasm .
    • 组织表达：
    • Expressed in brain, and to a lesser extent in lung, kidney and testis.

    相关报价

    • 货号：
    • KA1177C
    • 规格：
    • 96 / well
    • 价格：
    • ¥4700
    • 货期：
    • 预计发货时间为
      2024-05-19
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