EphA4 Monoclonal Antibody

    • 货号:YM0224
    • 应用:WB;ELISA
    • 种属:Human
      • 靶点:
      • EphA4
      • 简介:
      • >>Axon guidance
      • 基因名称:
      • EPHA4
      • 蛋白名称:
      • Ephrin type-A receptor 4
      • Human Gene Id:
      • 2043
      • Human Swiss Prot No:
      • P54764
      • Mouse Swiss Prot No:
      • Q03137
      • 免疫原:
      • Purified recombinant fragment of EphA4 (aa777-986) expressed in E. Coli.
      • 特异性:
      • EphA4 Monoclonal Antibody detects endogenous levels of EphA4 protein.
      • 组成:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • 来源:
      • Monoclonal, Mouse
      • 稀释:
      • WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
      • 纯化工艺:
      • Affinity purification
      • 储存:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • 其他名称:
      • EPHA4;HEK8;SEK;TYRO1;Ephrin type-A receptor 4;EPH-like kinase 8;EK8;hEK8;Tyrosine-protein kinase TYRO1;Tyrosine-protein kinase receptor SEK
      • 分子量:
      • 110kD
      • 背景:
      • This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015],
      • 功能:
      • catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,domain:The protein kinase domain mediates interaction with NGEF/ephexin-1.,function:Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A4 and -A5. Binds more poorly to ephrin-A2 and -A3. May play a role in a signal transduction process involved in hindbrain pattern formation.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,subunit:Interacts with the src family kinase, p59-Fyn, through the major phosphorylation site at position Tyr-602. Interacts with NGEF/ephexin-1.,tissue specificity:Ubiquitous.
      • 细胞定位:
      • Cell membrane ; Single-pass type I membrane protein . Cell projection, axon . Cell projection, dendrite . Cell junction, synapse, postsynaptic density membrane . Early endosome . Cell junction, adherens junction . Clustered upon activation and targeted to early endosome. .
      • 组织表达:
      • Ubiquitous.

      Identification of WISP1 as a novel oncogene in glioblastoma. INTERNATIONAL JOURNAL OF ONCOLOGY Int J Oncol. 2017 Oct;51(4):1261-1270 WB Human 1:1000 U251 cell, U373-MG cell
      货号:YM0224

      • 产品图片
      • Western Blot analysis using EphA4 Monoclonal Antibody against truncated Trx-EphA4 recombinant protein (1) and truncated GST-EphA4(aa777-986) recombinant protein (2).