• 靶点：
• Claudin 1

• 简介：
• >>Cell adhesion molecules;>>Tight junction;>>Leukocyte transendothelial migration;>>Pathogenic Escherichia coli infection;>>Hepatitis C

• 基因名称：
• CLDN1

• 蛋白名称：
• Claudin-1

• Human Gene Id：
• 9076

• Human Swiss Prot No：
• O95832

• Mouse Gene Id：
• 12737

• Mouse Swiss Prot No：
• O88551

• Rat Gene Id：
• 65129

• Rat Swiss Prot No：
• P56745

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human Claudin 1. AA range:162-211

• 特异性：
• Claudin-1 Polyclonal Antibody detects endogenous levels of Claudin-1 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000. IF 1:100-300 Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CLDN1;CLD1;SEMP1;Claudin-1;Senescence-associated epithelial membrane protein

• 实测条带：
• 22kD

• 背景：
• Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq, Jul 2008],

• 功能：
• disease:Defects in CLDN1 are the cause of ichthyosis-sclerosing cholangitis neonatal syndrome (NISCH) [MIM:607626]; also called ichthyosis with leukocyte vacuoles alopecia and sclerosing cholangitis (ILVASC). NISCH is a rare autosomal recessive complex ichthyosis syndrome characterized by scalp hypotrichosis, scarring alopecia, vulgar type ichthyosis, and sclerosing cholangitis.,function:Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity (By similarity). Acts as a co-receptor for HCV entry into hepatic cells.,similarity:Belongs to the claudin family.,subunit:Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN2, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ and INADL (By similarity). May interact with HCV E1 an

• 细胞定位：
• Cell junction, tight junction . Cell membrane ; Multi-pass membrane protein . Basolateral cell membrane . Associates with CD81 and the CLDN1-CD81 complex localizes to the basolateral cell membrane. .

• 组织表达：
• Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis.

Puerariae lobatae Radix Alleviates Pre-Eclampsia by Remodeling Gut Microbiota and Protecting the Gut and Placental Barriers
货号：YT0942

Afatinib Reverses EMT via Inhibiting CD44-Stat3 Axis to Promote Radiosensitivity in Nasopharyngeal Carcinoma Pharmaceuticals Huichao Huang, Fangling Huang, Xujun Liang, Ying Fu, Zhe Cheng, Yan Huang, Zhuchu Chen, Yankun Duan, Yongheng Chen WB Human 5-8F cell, HNE2 cell
货号：YT0942

Sucralose enhances the susceptibility to dextran sulfate sodium (DSS) induced colitis in mice with changes in gut microbiota. Food & Function Food Funct. 2021 Oct;12(19):9380-9390 WB,IHC Mouse 1:100 Colonic tissue
货号：YT0942

Changes in the Gut Microbiome Contribute to the Development of Behcet’s Disease via Adjuvant Effects. Frontiers in Cell and Developmental Biology Front Cell Dev Biol. 2021 Sep;0:2482 WB Mouse 1:1000 Colon
货号：YT0942

Liu, Mei-Ling, et al. "Protective effects of a novel probiotics Lactococcus lactis ML2018 in colitis: in vivo and in vitro evidence." Food & Function (2019).
货号：YT0942

Bacillus subtilis RZ001 improves intestinal integrity and alleviates colitis by inhibiting the Notch signalling pathway and activating ATOH-1. Pathogens and Disease Pathog Dis. 2020 Mar;78(2): WB Human HT-29 cell
货号：YT0942

The Synbiotic Combination of probiotics and inulin Improves NAFLD though Modulating Gut Microbiota JOURNAL OF NUTRITIONAL BIOCHEMISTRY Can Zhang
货号：YT0942

Palmatine ameliorated lipopolysaccharide-induced sepsis-associated encephalopathy mice by regulating the microbiota-gut-brain axis PHYTOMEDICINE Yubin Xu IHC Mouse brain tissue
货号：YT0942

• June 19-2018
• WESTERN IMMUNOBLOTTING PROTOCOL

• June 19-2018
• IMMUNOHISTOCHEMISTRY-PARAFFIN PROTOCOL

• June 19-2018
• IMMUNOFLUORESCENCE PROTOCOL

• September 08-2020
• FLOW-CYTOMEYRT-PROTOCOL

• May 20-2022
• Cell-Based ELISA│解您多样本WB检测之困扰

• July 13-2018
• CELL-BASED-ELISA-PROTOCOL-FOR-ACETYL-PROTEIN

• July 13-2018
• CELL-BASED-ELISA-PROTOCOL-FOR-PHOSPHO-PROTEIN

• July 13-2018
• CELL-BASED-COLORIMETRIC-ELISA-PROTOCOL-FOR-TOTAL-PROTEIN

• July 13-2018
• Antibody-FAQs