FGF-23 Polyclonal Antibody

    • 货号:YT1699
    • 应用:WB;IF;ELISA
    • 种属:Human;Mouse;Rat
      • 靶点:
      • FGF-23
      • 简介:
      • >>MAPK signaling pathway;>>Ras signaling pathway;>>Rap1 signaling pathway;>>Calcium signaling pathway;>>PI3K-Akt signaling pathway;>>Regulation of actin cytoskeleton;>>Parathyroid hormone synthesis, secretion and action;>>Pathways in cancer;>>Melanoma;>>Breast cancer;>>Gastric cancer
      • 基因名称:
      • FGF23
      • 蛋白名称:
      • Fibroblast growth factor 23
      • Human Gene Id:
      • 8074
      • Human Swiss Prot No:
      • Q9GZV9
      • Mouse Swiss Prot No:
      • Q9EPC2
      • 免疫原:
      • The antiserum was produced against synthesized peptide derived from human FGF23. AA range:151-200
      • 特异性:
      • FGF-23 Polyclonal Antibody detects endogenous levels of FGF-23 protein.
      • 组成:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • 来源:
      • Polyclonal, Rabbit,IgG
      • 稀释:
      • WB 1:500 - 1:2000. ELISA: 1:20000. IF 1:100-300 Not yet tested in other applications.
      • 纯化工艺:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • 浓度:
      • 1 mg/ml
      • 储存:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • 其他名称:
      • FGF23;HYPF;Fibroblast growth factor 23;FGF-23;Phosphatonin;Tumor-derived hypophosphatemia-inducing factor
      • 实测条带:
      • 27kD
      • 背景:
      • This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC). [provided by RefSeq, Feb 2013],
      • 功能:
      • disease:Defects in FGF23 are a cause of hyperphosphatemic familial tumoral calcinosis (HFTC) [MIM:211900]. HFTC is a severe autosomal recessive metabolic disorder that manifests with hyperphosphatemia and massive calcium deposits in the skin and subcutaneous tissues.,disease:Defects in FGF23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR) [MIM:193100]. ADHR is characterized by low serum phosphorus concentrations, rickets, osteomalacia, leg deformities, short stature, bone pain and dental abscesses.,PTM:After secretion it is processed into a N-terminal fragment and a C-terminal fragment. The processing is effected by the proprotein convertases.,similarity:Belongs to the heparin-binding growth factors family.,
      • 细胞定位:
      • Secreted . Secretion is dependent on O-glycosylation.
      • 组织表达:
      • Expressed in osteogenic cells particularly during phases of active bone remodeling. In adult trabecular bone, expressed in osteocytes and flattened bone-lining cells (inactive osteoblasts).

      Effects of selenium-cadmium co-enriched Cardamine hupingshanensis on bone damage in mice ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY Lin Zhang WB Mouse 1:1000 kidney tissue
      货号:YT1699

      • 产品图片
      • Immunofluorescence analysis of A549. 1,primary Antibody was diluted at 1:200(4°C overnight). 2, Goat Anti Rabbit IgG (H&L) - Alexa Fluor 488 Secondary antibody was diluted at 1:1000(room temperature, 50min).3, Picture B: DAPI(blue) 10min.
      • Western blot analysis of lysates from Jurkat cells, primary antibody was diluted at 1:1000, 4°over night