• 靶点：
• GDF-8

• 简介：
• >>Cytokine-cytokine receptor interaction

• 基因名称：
• MSTN

• 蛋白名称：
• Growth/differentiation factor 8

• Human Gene Id：
• 2660

• Human Swiss Prot No：
• O14793

• Mouse Gene Id：
• 17700

• Mouse Swiss Prot No：
• O08689

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human GDF-8. AA range:38-87

• 特异性：
• GDF-8 Polyclonal Antibody detects endogenous levels of GDF-8 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:10000. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• MSTN;GDF8;Growth/differentiation factor 8;GDF-8;Myostatin

• 分子量：
• 43kD

• 背景：
• myostatin(MSTN) Homo sapiens This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals. [provided by RefSeq, Jul 2016],

• 功能：
• function:Acts specifically as a negative regulator of skeletal muscle growth.,online information:Myostatin entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked (By similarity). Interacts with WFIKKN2, leading to inhibit its activity.,

• 细胞定位：
• Secreted .

• 组织表达：
• Colon,Muscle,Pericardium,Skeletal muscle,

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