• 靶点：
• GIMAP5

• 基因名称：
• GIMAP5

• 蛋白名称：
• GTPase IMAP family member 5

• Human Gene Id：
• 55340

• Human Swiss Prot No：
• Q96F15

• Mouse Swiss Prot No：
• Q8BWF2

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human GIMAP5. AA range:231-280

• 特异性：
• GIMAP5 Polyclonal Antibody detects endogenous levels of GIMAP5 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• GIMAP5;IAN4L1;IAN5;IMAP3;GTPase IMAP family member 5;Immunity-associated nucleotide 4-like 1 protein;Immunity-associated nucleotide 5 protein;IAN-5;hIAN5;Immunity-associated protein 3

• 实测条带：
• 35kD

• 背景：
• This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. This gene encodes an antiapoptotic protein that functions in T-cell survival. Polymorphisms in this gene are associated with systemic lupus erythematosus. Read-through transcription exists between this gene and the neighboring upstream GIMAP1 (GTPase, IMAP family member 1) gene. [provided by RefSeq, Dec 2010],

• 功能：
• function:Required for mitochondrial integrity and T-cell survival. May contribute to T-cell quiescence.,similarity:Belongs to the IAN GTP-binding protein family.,tissue specificity:Widely expressed with high levels in lymph node and spleen. High expression found in CD4 and CD8-positive T-cells and monocytes with very low levels in B-lymphocytes. Highly expressed in B-lymphocyte-derived neoplasms.,

• 细胞定位：
• Lysosome membrane ; Single-pass type IV membrane protein . Endosome, multivesicular body membrane ; Single-pass type IV membrane protein . Endosome membrane ; Single-pass type IV membrane protein . The mitochondrial localization originally reported was observed with C-terminally tagged protein and was not confirmed in later publications. .

• 组织表达：
• Widely expressed with high levels in lymph node and spleen (PubMed:14724691). High expression found in T lymphocytes, including CD4 and CD8-positive T-cells, and monocytes (PubMed:14724691, PubMed:29382851). Very low expression levels in B-lymphocytes (PubMed:14724691).

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