NKp30 Polyclonal Antibody
- 货号：YT3135
- 应用：WB;ELISA
- 种属：Human;Rat
- 简介：
- >>Natural killer cell mediated cytotoxicity
- 蛋白名称：
- Natural cytotoxicity triggering receptor 3
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human NCR3. AA range:104-153
- 特异性：
- NKp30 Polyclonal Antibody detects endogenous levels of NKp30 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- NCR3;1C7;LY117;Natural cytotoxicity triggering receptor 3;Activating natural killer receptor p30;Natural killer cell p30-related protein;NK-p30;NKp30;CD antigen CD337
- 背景：
- The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010],
- 功能：
- function:Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.,polymorphism:A genetic variation in NCR3 is associated with mild malaria suceptibility [MIM:609148].,similarity:Belongs to the natural cytotoxicity receptor (NCR) family.,similarity:Contains 1 Ig-like (immunoglobulin-like) domain.,subunit:Interacts with CD3Z.,tissue specificity:Selectively expressed by all resting and activated NK cells and weakly expressed in spleen.,
- 细胞定位：
- Cell membrane ; Single-pass type I membrane protein .
- 组织表达：
- Selectively expressed by all resting and activated NK cells and weakly expressed in spleen.
- Western blot analysis of the lysates from K562 cells using NCR3 antibody.
