• 靶点：
• TrxR2

• 简介：
• >>Selenocompound metabolism;>>Pathways in cancer;>>Hepatocellular carcinoma

• 基因名称：
• TXNRD2

• 蛋白名称：
• Thioredoxin reductase 2 mitochondrial

• Human Gene Id：
• 10587

• Human Swiss Prot No：
• Q9NNW7

• Mouse Gene Id：
• 26462

• Mouse Swiss Prot No：
• Q9JLT4

• Rat Gene Id：
• 50551

• Rat Swiss Prot No：
• Q9Z0J5

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human TRXR2. AA range:471-520

• 特异性：
• TrxR2 Polyclonal Antibody detects endogenous levels of TrxR2 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• TXNRD2;KIAA1652;TRXR2;Thioredoxin reductase 2; mitochondrial;Selenoprotein Z;SelZ;TR-beta;Thioredoxin reductase TR3

• 实测条带：
• 56kD

• 背景：
• thioredoxin reductase 2(TXNRD2) Homo sapiens This gene encodes a member of the class I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein is a selenocysteine-containing flavoenzyme that maintains thioredoxins in a reduced state, thereby playing a key role in regulating the cellular redox environment. Mammals have three related thioredoxin reductases. This gene encodes a mitochondrial form important for scavenging of reactive oxygen species in mitochondria. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2013],

• 功能：
• catalytic activity:Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH.,cofactor:FAD.,function:Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox-regulated cell signaling.,miscellaneous:The active site is a redox-active disulfide bond. The selenocysteine residue is essential for enzymatic activity.,sequence caution:Translated as Sec.,similarity:Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.,subunit:Homodimer.,tissue specificity:Highly expressed in the prostate, ovary, liver, testis, uterus, colon and small intestine. Intermediate levels in brain, skeletal muscle, heart and spleen. Low levels in placenta, pancreas, thymus and peripheral blood leukocytes. According to PubMed:10608886, high levels in kidney, whereas according to PubMed:9923614 levels are low.,

• 细胞定位：
• Mitochondrion .

• 组织表达：
• Highly expressed in the prostate, ovary, liver, testis, uterus, colon and small intestine. Intermediate levels in brain, skeletal muscle, heart and spleen. Low levels in placenta, pancreas, thymus and peripheral blood leukocytes. According to PubMed:10608886, high levels in kidney, whereas according to PubMed:9923614, levels are low. High expression is observed in the adrenal cortex (PubMed:24601690).

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