• 靶点：
• ST6GAL1

• 简介：
• >>N-Glycan biosynthesis;>>Other types of O-glycan biosynthesis;>>Metabolic pathways

• 基因名称：
• ST6GAL1 SIAT1

• 蛋白名称：
• ST6GAL1

• Human Gene Id：
• 6480

• Human Swiss Prot No：
• P15907

• Mouse Gene Id：
• 20440

• Mouse Swiss Prot No：
• Q64685

• Rat Swiss Prot No：
• P13721

• 免疫原：
• Synthetic peptide from human protein at AA range: 63-135

• 特异性：
• The antibody detects endogenous ST6GAL1

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• IHC 1:50-200, ELISA 1:10000-20000,WB 1:500-2000. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Beta-galactoside alpha-2,6-sialyltransferase 1 (Alpha 2,6-ST 1;EC 2.4.99.1;B-cell antigen CD75;CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1;ST6Gal I;ST6GalI;Sialyltransferase 1)

• 分子量：
• 47kD

• 背景：
• This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Three transcript variants encoding two different isoforms have been described. [provided by RefSeq, Aug 2009],

• 功能：
• catalytic activity:CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine.,function:Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates.,online information:GlycoGene database,online information:ST6Gal I,pathway:Protein modification; protein glycosylation.,PTM:The HB-6, CDW75, and CD76 differentiation antigens are cell-surface carbohydrate determinants generated by this enzyme.,PTM:The soluble form derives from the membrane form by proteolytic processing.,similarity:Belongs to the glycosyltransferase 29 family.,subcellular location:Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.,

• 细胞定位：
• Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein . Secreted. Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.

• 组织表达：
• Liver,Lymph,Placenta,Skin,Spleen,Thymus,

Development of a novel method to evaluate sialylation of glycoproteins and analysis of gp96 sialylation in Hela, SW1990 and A549 cell lines. BIOLOGICAL RESEARCH Biol Res. 2015 Dec;48(1):1-9 WB Human 1:1000 HeLa cell,A549 cell, SW1990 cell
货号：YT5847

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