Collagen Type IV (ABT165) IHC kit
- Catalog No.:IHCM6941
- Applications:IHC
- Reactivity:Human (predicted: Mouse)
- Target:
- Collagen IV
- Fields:
- >>PI3K-Akt signaling pathway;>>Focal adhesion;>>ECM-receptor interaction;>>Relaxin signaling pathway;>>AGE-RAGE signaling pathway in diabetic complications;>>Protein digestion and absorption;>>Amoebiasis;>>Human papillomavirus infection;>>Pathways in cancer;>>Small cell lung cancer
- Gene Name:
- COL4A1
- Protein Name:
- Collagen Type IV
- Human Gene Id:
- 1282
- Human Swiss Prot No:
- P02462
- Immunogen:
- Synthesized peptide derived from human Collagen Type IV AA range: 1600-1669
- Specificity:
- The antibody can specifically recognize human Collagen Type IV protein, collagen types I, II, III and V do not respond to the anbody.. The antibody was also Predict react with Mouse
- Source:
- Mouse, Monoclonal/IgG2b, Kappa
- Purification:
- The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
- Storage Stability:
- 2°C to 8°C/1 year
- Other Name:
- Collagen alpha-1(IV) chain [Cleaved into: Arresten]
- Background:
- This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],
- Function:
- disease:Defects in COL4A1 are a cause of brain small vessel disease with hemorrhage [MIM:607595]. Brain small vessel diseases underlie 20 to 30 percent of ischemic strokes and a larger proportion of intracerebral hemorrhages. Inheritance is autosomal dominant.,disease:Defects in COL4A1 are a cause of porencephaly type 1 [MIM:175780]; also known as encephaloclastic porencephaly. Porencephaly is a term used for any cavitation or cerebrospinal fluid-filled cyst in the brain. Porencephaly type 1 is usually unilateral and results from focal destructive lesions such as fetal vascular occlusion or birth trauma. Inheritance is autosomal dominant.,disease:Defects in COL4A1 are the cause of hereditary angiopathy with nephropathy, aneurysms, and muscle cramps (HANAC) [MIM:611773]. The clinical renal manifestations include hematuria and bilateral large cysts. Histologic analysis revealed complex bas
- Subcellular Location:
- Cytoplasmic
- Expression:
- Highly expressed in placenta.
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- Antibody-FAQs
- Products Images
- Human placenta tissue was stained with Anti-Collagen Type IV (ABT165) Antibody