Phospho SHP-1 (Y536) Cell-Based Colorimetric ELISA Kit

  • Catalog No.：KA1180C
  • Applications：ELISA
  • Reactivity：Human;Mouse;Rat
    • Gene Name：
    • PTPN6
    • Human Gene Id：
    • 5777
    • Human Swiss Prot No：
    • P29350
    • Mouse Swiss Prot No：
    • P29351
    • Storage Stability：
    • 2-8°C/6 months
    • Other Name：
    • Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1)
    • Detection Method：
    • Colorimetric
    • Background：
    • catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,function:Plays a key role in hematopoiesis. This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation.,PTM:Phosphorylated on serine and tyrosine residues.,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.,similarity:Contains 1 tyrosine-protein phosphatase domain.,similarity:Contains 2 SH2 domains.,subcellular location:In neurons, translocates into the nucleus after treatment with angiotensin II.,subunit:Monomer. Interacts with MTUS1 (By similarity). Binds PTPNS1, LILRB1 and LILRB2. Interacts with FCRL2, FCRL3, FCRL4, CD300LF and CD84.,tissue specificity:Isoform 1 is expressed in hematopoietic cells while isoform 2 is expressed in non-hematopoietic cells.,
    • Function：
    • protein amino acid dephosphorylation, phosphorus metabolic process, phosphate metabolic process, apoptosis, cell surface receptor linked signal transduction, G-protein coupled receptor protein signaling pathway, cell death, negative regulation of cell proliferation, response to wounding, programmed cell death, death, dephosphorylation, regulation of cell proliferation,
    • Subcellular Location：
    • Cytoplasm. Nucleus. In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity). Shuttles between the cytoplasm and nucleus via its association with PDPK1. .
    • Expression：
    • Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.

    Attributes

    • Code：
    • KA1180C
    • Size
    • 96 / well
    • Price$：
    • 470
    • Delivery：
    • 2024-12-07
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