• Target：
• CD269/BCMA

• Gene Name：
• TNFRSF17 BCM BCMA

• Protein Name：
• Tumor necrosis factor receptor superfamily member 17 (B-cell maturation protein) (CD antigen CD269)

• Human Gene Id：
• 608

• Human Swiss Prot No：
• Q02223

• Immunogen：
• Purified recombinant Human CD269

• Specificity：
• This recombinant monoclonal antibody can detects endogenous levels of CD269/BCMA protein.

• Formulation：
• Phosphate-buffered solution

• Source：
• Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell

• Dilution：
• ELISA 1:5000-100000;FCM 1-2μg/Test

• Purification：
• Recombinant Expression and Affinity purified

• Concentration：
• Please check the information on the tube

• Storage Stability：
• -15°C to -25°C/1 year(Avoid freeze / thaw cycles)

• Other Name：
• TNFRSF17;BCM;BCMA;Tumor necrosis factor receptor superfamily member 17;B-cell maturation protein;CD269;CD269 nanobody;BCMA nanobody;

• Background：
• The protein encoded byThis gene is a member of the TNF-receptor superfamily.This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response.This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation.This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]

• Function：
• disease:A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.,Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.,similarity:Contains 1 TNFR-Cys repeat.,subcellular location:Perinuclear Golgi-like structures.,subunit:Associates with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6.,tissue specificity:Expressed in mature B-cells, but not in T-cells or monocytes.,

• Subcellular Location：
• Cell membrane; Single-pass type III membrane protein. Endomembrane system; Single-pass type III membrane protein. Perinuclear Golgi-like structures.

• Expression：
• Expressed in mature B-cells, but not in T-cells or monocytes.

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