Recombinant SARS-CoV-2(Covid-19) S1 Protein

  • Catalog No.:YD2191
  • Applications:ELISA ECL Immunogold
  • Reactivity:Human virus
    • Purity:
    • >90% as determined by SDS-PAGE
    • Fields:
    • For research use only .Not for use in clinical diagnostic procedures.
    • Gene Name:
    • S
    • Protein Name:
    • Spike glycoprotein,Spike protein S1(S1) Surface glycoprotein
    • Source:
    • Mammalian cells
    • Dilution:
    • Testing in progress
    • Concentration:
    • >90% as determined by SDS-PAGE
    • Storage Stability:
    • Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week . Store at -20 to -80 °C for twelve months from the date of receipt.
    • Molecular Weight(Da):
    • 105kDa
    • Observed Band(KD):
    • 130-140kDa
    • Background:
    • Recombinant SARS-CoV-2 S1 Protein is produced by Mammalian cells expression system and the target gene encoding Met1-Tyr695 is expressed with C-Fc Tag
    • Function:
    • Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor.