Recombinant Human ACE2 protein

  • Catalog No.:YD2195
  • Applications:ELISA ECL Immunogold
  • Reactivity:Human
    • Purity:
    • >90% as determined by SDS-PAGE
    • Fields:
    • For research use only .Not for use in clinical diagnostic procedures.
    • Gene Name:
    • ACE2
    • Protein Name:
    • ACE-related carboxypeptidase Angiotensin-converting enzyme homolog Metalloprotease MPROT15
    • Human Swiss Prot No:
    • Q9BYF1
    • Mouse Swiss Prot No:
    • Q8R0I0
    • Source:
    • Mammalian cells
    • Dilution:
    • Testing in progress
    • Concentration:
    • >90% as determined by SDS-PAGE
    • Storage Stability:
    • Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week . Store at -20 to -80 °C for twelve months from the date of receipt.
    • Molecular Weight(Da):
    • 86.28kDa
    • Observed Band(KD):
    • 100-110kDa
    • Background:
    • Recombinant Human ACE2 is produced by Mammalian cells expression system and the target gene encoding Met1-Ser740 is expressed with C-HisTag
    • Function:
    • Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.