CD28-FC recombinant protein
- Catalog No.:YD3067
- Reactivity:Human;
- Purity:
- >90% as determined by SDS-PAGE
- Protein Name:
- T-cell-specific surface glycoprotein CD28 (TP44) (CD antigen CD28)
- Sequence:
- Amino acid:19-152,with FC tag.
- Formulation:
- Phosphate-buffered solution
- Storage Stability:
- -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
- Other Name:
- T-cell-specific surface glycoprotein CD28 ;TP44;CD antigen CD28;CD28;
- Function:
- Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933). Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037).
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.; [Isoform 3]: Cell surface .
- Expression:
- Expressed in T-cells and plasma cells, but not in less mature B-cells.