CD131-FC recombinant protein
- Catalog No.：YD3094
- Reactivity：Human;
- Purity：
- >90% as determined by SDS-PAGE
- Protein Name：
- Cytokine receptor common subunit beta (CDw131) (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131)
- Sequence：
- Amino acid:17-443,with FC tag.
- Formulation：
- Phosphate-buffered solution
- Storage Stability：
- -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
- Other Name：
- Cytokine receptor common subunit beta ;CDw131;GM-CSF/IL-3/IL-5 receptor common beta subunit;CD antigen CD131;CSF2RB;IL3RB;IL5RB;
- Function：
- Cell surface receptor that plays a role in immune response and controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA (PubMed:1495999). In turn, participates in various signaling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways. In unstimulated conditions, interacts constitutively with JAK1 and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK-STAT pathway (PubMed:9516124).
- Subcellular Location：
- Membrane; Single-pass type I membrane protein.
