VE-cadherin rabbit-FC recombinant protein

  • Catalog No.：YD3112
  • Reactivity：Human;
    • Purity：
    • >90% as determined by SDS-PAGE
    • Gene Name：
    • VE-cadherin
    • Protein Name：
    • Cadherin-5 (7B4 antigen) (Vascular endothelial cadherin) (VE-cadherin) (CD antigen CD144)
    • Sequence：
    • Amino acid:48-300,with rabbit FC tag.
    • Human Gene Id：
    • 1003
    • Human Swiss Prot No：
    • P33151
    • Formulation：
    • Phosphate-buffered solution
    • Source：
    • Mammalian cells
    • Storage Stability：
    • -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
    • Other Name：
    • Cadherin-5 (7B4 antigen;Vascular endothelial cadherin;VE-cadherin;CD antigen CD144)
    • Background：
    • This gene encodes a classical cadherin of the cadherin superfamily. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner, this protein plays a role in endothelial adherens junction assembly and maintenance. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. [provided by RefSeq, Nov 2015],
    • Function：
    • function:Cadherins are calcium dependent cell adhesion proteins.,function:Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton.,similarity:Contains 5 cadherin domains.,subcellular location:Found at cell-cell boundaries and probably at cell-matrix boundaries.,tissue specificity:Endothelial tissues and brain.,
    • Subcellular Location：
    • Cell junction . Cell membrane ; Single-pass type I membrane protein . Found at cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions. .
    • Expression：
    • Endothelial tissues and brain.

    Attributes

    • Code：
    • YD3112
    • Size
    • 5μg / 50μg / 500μg
    • Price$：
    • 52 / 272 / 1356
    • Delivery：
    • 2024-11-23
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