LSD1 rabbit-FC recombinant protein
- Catalog No.：YD3141
- Reactivity：Human;
- Purity：
- >90% as determined by SDS-PAGE
- Protein Name：
- Lysine-specific histone demethylase 1A
- Sequence：
- Amino acid:21-210,with rabbit FC tag.
- Formulation：
- Phosphate-buffered solution
- Storage Stability：
- -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
- Other Name：
- KDM1A;AOF2;KDM1;KIAA0601;LSD1;Lysine-specific histone demethylase 1A;BRAF35-HDAC complex protein BHC110;Flavin-containing amine oxidase domain-containing protein 2
- Background：
- This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009],
- Function：
- cofactor:FAD.,domain:The SWIRN domain may act as an anchor site for a histone tail.,function:Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3 'Lys-4' on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. May also demethylate 'Lys-9' of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to derepression of androgen receptor target genes. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediate
- Subcellular Location：
- Nucleus .
- Expression：
- Ubiquitously expressed.
