• Target：
• Stat6

• Fields：
• >>Necroptosis;>>JAK-STAT signaling pathway;>>Th1 and Th2 cell differentiation;>>Th17 cell differentiation;>>Hepatitis B;>>Pathways in cancer;>>Inflammatory bowel disease

• Gene Name：
• STAT6

• Protein Name：
• Signal transducer and activator of transcription 6

• Human Gene Id：
• 6778

• Human Swiss Prot No：
• P42226

• Mouse Gene Id：
• 20852

• Mouse Swiss Prot No：
• P52633

• Immunogen：
• Purified recombinant fragment of human Stat6 expressed in E. Coli.

• Specificity：
• Stat6 Monoclonal Antibody detects endogenous levels of Stat6 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• STAT6;Signal transducer and activator of transcription 6;IL-4 Stat

• Molecular Weight(Da)：
• 94kD

• References：
• 1. Pediatr Nephrol. 2009 Mar;24(3):489-95.
  2. Mol Immunol. 2009 Jun;46(10):2080-9.
  3. Am J Hum Genet. 2009 Nov;85(5):628-42.

• Background：
• The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010],

• Function：
• function:Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling.,PTM:Tyrosine phosphorylated following stimulation by IL-4 and IL-3.,similarity:Belongs to the transcription factor STAT family.,similarity:Contains 1 SH2 domain.,subcellular location:Translocated into the nucleus in response to phosphorylation.,subunit:Forms a homodimer or a heterodimer with a related family member (By similarity). Interacts with NCOA1 via its C-terminal LXXLL motif.,

• Subcellular Location：
• Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.

• Expression：
• Uterus,

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